Topicort and Pregnancy

In studies, giving Topicort (desoximetasone) to pregnant animals increased the risk for birth defects and other problems. Due to these potential risks, this drug is considered a pregnancy Category C medicine, meaning it may not be safe for use during pregnancy. If you are pregnant and using Topicort, it is typically recommended to use only the smallest amount for the shortest possible time.

Can Pregnant Women Use Topicort?

Topicort® (desoximetasone) is a prescription topical steroid approved for treating a wide variety of skin conditions. Based on information currently available, it is unclear if the drug is safe for use during pregnancy. As with most medications, it should be used only if necessary, at the lowest effective dose, and for the shortest possible time during pregnancy.
Depending on the strength and form, some Topicort products are high-potency steroids and some are medium-potency steroids (see Topicort Uses for more information). As a general guideline, pregnant women should usually be treated with the least-potent steroid that is effective for them.

What Is Pregnancy Category C?

Topicort is classified as a pregnancy Category C drug. The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken used pregnancy. Pregnancy Category C is given to medicines that have not been adequately studied in pregnant humans but have caused fetal harm in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Animal studies have shown that steroids, including Topicort, may increase the risk for birth defects (such as cleft palate) and may cause other problems (such as poor fetal growth) or decreased survival. Similar problems might also occur in humans, although the risk is probably smaller for topical steroids that are applied to the skin (like Topicort).
While short-term use (a few days) of the medication applied to a small area of the body is probably not likely to cause problems, extended use or use over a large area of the body should probably be avoided during pregnancy.
Pregnancy and Pain

Topicort Drug Information

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