Taclonex and Pregnancy

The FDA has given Taclonex (calcipotriene/betamethasone dipropionate) a pregnancy Category C rating. This means that it may be used during pregnancy. In fact, one of the active ingredients in this drug is often given to help develop the lungs of a baby who will likely be born prematurely. However, it's still a good idea to consult your doctor before using it when pregnant.

Can Pregnant Women Use Taclonex?

Taclonex® (calcipotriene/betamethasone dipropionate) is a prescription psoriasis medication that is applied to the skin. Based on the results of animal studies and the known risks from other similar medications, it may present some risks to the fetus when taken during pregnancy, although the full risks are currently unknown.
 

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies.
 
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
 
Giving calcipotriene (one of the active ingredients in Taclonex) to pregnant rabbits increased the risk of various bone abnormalities, which might be expected since Taclonex is a synthetic form of vitamin D that can affect how the body handles calcium. It is unclear whether such problems are possible or likely with human use.
 
Betamethasone (the other active ingredient in Taclonex) is a steroid. Animal studies have shown that steroids may increase the risk of birth defects. Similar problems might also occur in humans, although the risk is probably smaller with topical steroids that are applied to the skin, like Taclonex.
 
Interestingly, betamethasone is often used to help mature the fetal lungs in babies that will probably be born prematurely. In this situation, usually a single dose is given by injection.
 
It is important to note that animals do not always respond to medicines the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.
 
Pregnancy and Pain

Taclonex Medication Information

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