Precautions and Warnings With Methotrexate

Who Should Not Take Methotrexate?

You should avoid methotrexate if you:
  • Are allergic to it, Rheumatrex, Trexall, or any inactive ingredients used in making these products. Your healthcare provider or pharmacist has a list of the inactive ingredients.
  • Have a weakened immune system.
  • Have alcoholism.
  • Have chronic liver disease.
  • Have low blood cell counts (when used to treat psoriasis or rheumatoid arthritis).
  • Are pregnant (when used to treat psoriasis or rheumatoid arthritis).
  • Are breastfeeding (although some sources considerer methotrexate acceptable for use during breastfeeding in some situations).
Although this medication is not recommended for treating psoriasis or rheumatoid arthritis in people with low blood cell counts or in pregnant women, it can be used to treat more serious conditions (such as cancer) in such people if the potential benefits outweigh the likely risks.

Final Thoughts

There are a number of situations in which methotrexate should not be taken, along with several safety concerns people should be aware of before beginning treatment. However, it is possible that not all of these issues were discussed in this article. Therefore, you should talk with your healthcare provider about the specific warnings and precautions for methotrexate that may apply to you.
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