Methotrexate Serious Side Effects

Methotrexate (Rheumatrex®, Trexall®) is a powerful drug that kills both cancer cells and healthy cells. In fact, it is so potent that it is usually reserved for treating severe diseases in cases where other treatments have failed or are not appropriate. Because it is such a strong medication, serious side effects can sometimes occur with methotrexate, including:
  • Signs of liver fibrosis or cirrhosis (two types of liver damage), such as high liver enzymes or abnormal results from a liver biopsy
  • Severe vomiting, diarrhea, or mouth sores -- all of which may contribute to dehydration
  • Signs of low blood platelets or anemia, such as easy bruising or bleeding
  • Signs of low white blood cells, such as frequent infections.
(To learn more about these and other serious reactions, click Methotrexate Side Effects. This article offers a more in-depth list of potential side effects, including a list of symptoms that could be linked to the medication, but could also be symptoms of the underlying condition.)
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