Methotrexate Dosage

Your healthcare provider will consider several factors when determining your dosage of methotrexate, such as how much you weigh and the medical condition being treated. For psoriasis or rheumatoid arthritis treatment, the drug is usually taken once weekly, either as a single amount or split up into three doses taken separately. Make sure you understand your dosing instructions thoroughly, as errors can be quite dangerous.

An Overview of Dosing With Methotrexate

The dosage of methotrexate (Rheumatrex®, Trexall®) your healthcare provider recommends will vary, depending on several factors, such as:
 
  • The medical condition being treated
  • Your age and weight
  • How you tolerate this medication.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
 

Methotrexate Dosage for Psoriasis or Rheumatoid Arthritis

For psoriasis or rheumatoid arthritis, methotrexate is usually taken once a week, either as a single dose or split up into three doses taken every 12 hours. For adults with rheumatoid arthritis, a typical oral dosage is methotrexate 7.5 mg once weekly or 2.5 mg every 12 hours for three doses (once weekly).
 
For adults with psoriasis, a typical oral methotrexate dose is 10 to 25 mg once weekly or 2.5 mg every 12 hours for three doses (once weekly).
 
For children with rheumatoid arthritis, your child's healthcare provider will calculate an appropriate dosage based on the child's weight.
 
Make sure you understand your dosing instructions thoroughly, as errors can be quite dangerous. For instance, taking a weekly methotrexate dose every day could be fatal.
 
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Methotrexate Drug Information

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