Drug Interactions With Methotrexate

Salicylates
Salicylates may increase the toxicity of methotrexate. If you must take such medications together, your healthcare provider should monitor you closely.
 
Sulfasalazine
Combining sulfasalazine with methotrexate may increase the risk of liver damage. Check with your healthcare provider before taking these medications together.
 
Sulfonamides
Sulfonamides may increase the toxicity of methotrexate. If you must take such medications together, your healthcare provider should monitor you closely.
 
Theophylline
Methotrexate may increase the level of theophylline in your blood. Your healthcare provider may need to monitor your theophylline levels more closely and adjust your dosage as appropriate.
 

Final Thoughts

It is possible that not all interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with methotrexate that may apply to you.
 
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