Cyclosporine (Gengraf®, Neoral®, Sandimmune®) is a medicine prescribed to prevent organ rejection after a kidney, liver, or heart transplant. It is also used to relieve symptoms of severe psoriasis or severe, active rheumatoid arthritis that has not responded adequately to other treatments. It comes in the form of a capsule, an oral solution (liquid), and an intravenous (IV) injection.
Cyclosporine comes in two formulations: an original form (Sandimmune) and a modified version (Gengraf, Neoral) that is more easily absorbed into the body. Although most people tolerate cyclosporine well, side effects can occur and may include tremors, kidney problems, or excess facial or body hair.
Before taking cyclosporine, make sure your healthcare provider has up-to-date information on any other drugs you are taking (including vitamins and supplements), as well as any allergies you may have, including to medications, foods, dyes, or preservatives. Also, let your healthcare provider know if you are pregnant or breastfeeding.
(For more information on this drug, click Cyclosporine. This Web resource offers more details on how this medication works, dosing guidelines, and general safety precautions to be aware of before beginning treatment.)
Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: ArthurSchoenstadt, MD
List of references (click here):
Sandimmune [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2011 July.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed August 30, 2011.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed August 22, 2011.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed August 29, 2011.
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