Psoriasis Home > Olux Side Effects

A few of the reported side effects of Olux include suppression of the adrenal glands, burning, and other skin reactions. While many reactions to this medicine are usually minor, there are some potentially serious problems that require immediate medical care. Contact your healthcare provider right away if you experience side effects such as infections, severe fluid retention, or extreme aggression.

An Introduction to Olux Side Effects

Just like any medicine, Olux® (clobetasol propionate foam) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Olux. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Olux

Olux has been studied extensively in clinical trials. In these studies, one group of people received Olux, while another group was given a placebo (a similar product that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
The reported reactions in these studies varied, depending on the particular form of Olux (regular foam or alcohol-free emollient foam). The most common side effect of the regular Olux foam included:
  • Suppression of the adrenal glands -- in up to 100 percent of people
  • Burning -- up to 10 percent
  • Other skin reactions (not specified) -- up to 4 percent.
Hypothalamic-pituitary adrenal suppression (also known as HPA suppression) is serious but usually reversible (see the "Olux and HPA Suppression" section that follows for a more in-depth discussion of this problem). The high rate of suppression (up to 100 percent) was seen in studies of Olux for atopic dermatitis of the body, a condition for which the medication is not approved.
For Olux-E emollient foam, the most commonly reported side effects included:
  • Suppression of the adrenal glands -- in up to 16.2 percent of people
  • Weakening and thinning of the skin -- up to 1.9 percent
  • Skin reactions -- up to 1.6 percent.
In general, side effects are more common when a dressing, such as a bandage, is used to cover the medication. Do not use a dressing, unless your healthcare provider specifically recommends that you do so.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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