Psoriasis Home > Drug Interactions With Methotrexate

Several medications -- including NSAIDs, phenytoin, and aspirin -- can react negatively with methotrexate. Drug interactions can increase your risk of liver damage, dangerously low white blood cells, toxicity, and other problems. Talk with your healthcare provider if you are thinking of taking any other medications during treatment with methotrexate, including nonprescription ones.

An Overview of Methotrexate Interactions

Methotrexate (Rheumatrex®, Trexall®) can potentially interact with a number of other medicines. Products that may lead to methotrexate drug interactions can include but are not limited to:
  • Salicylates, such as:
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Bismuth subsalicylate (Pepto-Bismol®)
    • Choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
  • Theophylline (Uniphyl®, Theocron®, TheoCap®, Theo-24®, Elixophyllin®).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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