Psoriasis Home > Derma-Smoothe

Derma-Smoothe is a medication prescribed to treat scalp psoriasis and atopic dermatitis. This product comes as an oil that is applied one to three times daily, depending on the reason it is being used. It works by decreasing inflammation and suppressing an overactive immune system. Although most people tolerate this medicine well, side effects can occur and may include skin irritation, dryness, and burning.

What Is Derma-Smoothe?

Derma-Smoothe/FS® (fluocinolone oil) is a prescription medication that belongs to a group of drugs known as topical steroids. It contains fluocinolone acetonide, a potent corticosteroid.
Derma-Smoothe scalp oil is approved to treat scalp psoriasis in adults. The body oil is approved to treat atopic dermatitis (a type of eczema) in children and adults. Derma-Smoothe is a topical medicine, which means it is applied directly on the skin.
(Click Derma-Smoothe Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Derma-Smoothe is made by Hill Dermaceuticals, Inc.

How Does Derma-Smoothe Work?

Derma-Smoothe is part of a group of medications known as corticosteroids, or steroids for short. It works by decreasing inflammation and suppressing an overactive immune system. Conditions such as atopic dermatitis and psoriasis are thought to occur when the immune system has an overactive response to some kind of trigger, leading to symptoms such as redness, a rash, and itching. By suppressing the immune system and decreasing inflammation, Derma-Smoothe can reduce the symptoms of these conditions.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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