P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove cyclosporine from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
Taking cyclosporine with one of these Pgp inhibitors causes cyclosporine to be removed from the body more slowly, potentially increasing cyclosporine blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take cyclosporine with a Pgp inhibitor, and lower your dose if needed.
Taking cyclosporine with pimecrolimus may increase your risk for potentially serious cyclosporine side effects, including infections and skin cancer. Although the risk for these serious side effects is rare, it is typically recommended that pimecrolimus not be used with medicines that weaken the immune system, including cyclosporine.
Combining cyclosporine with a potassium-sparing diuretic increases the risk for high blood potassium levels (hyperkalemia). In general, these medicines should not be taken together.
Cyclosporine may increase the amount of silodosin in your blood, increasing your risk for side effects. It is generally recommended that these medicines not be used together.
Cyclosporine may increase blood levels of statin medicines, possibly increasing the risk for serious statin side effects. Cyclosporine should not be taken with simvastatin or pitavastatin. Other statins may require a dosage reduction if taken with cyclosporine.
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