Psoriasis Home > Amevive Uses

Amevive is one of the treatment options available for plaque psoriasis -- specifically, cases that are moderate to severe in nature. Healthcare providers use Amevive to prevent certain cells in the immune system (known as T-cells) from becoming activated; it is believed that an overactive immune system plays a role in causing psoriasis. At this time, the medication is approved for adults only.

What Is Amevive Used For?

Amevive® (alefacept) is a prescription medication licensed to treat moderate-to-severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy (medications that are taken by mouth or by injection).
Psoriasis is a chronic skin disease. There are several different types of psoriasis, but Amevive is only approved to treat plaque psoriasis.
The symptoms of psoriasis may vary, depending on the type. Plaque psoriasis is characterized by thickened, swollen, and red skin, often covered with silver scales. It is thought that psoriasis is caused by an overactive immune system (see Psoriasis Causes for more information).
Psoriasis treatment may include:
  • Light treatments (phototherapy)
  • Medicines applied to the skin (topical treatment)
  • Psoriasis medication, taken either by mouth or by injection, that treats the whole immune system (called systemic therapy).
Amevive is a type of systemic therapy.

How Does Amevive Work?

Amevive is a fusion protein. In other words, it is a part of an antibody that has been fused to a special protein. The medicine is thought to work by binding to T-cells (a certain type of immune system cell), preventing them from becoming activated and reducing their number. Overactive T-cells are believed play a large role in causing the symptoms of plaque psoriasis.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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