Locoid and Pregnancy

As a type of steroid, Locoid (hydrocortisone butyrate) may not be safe for use during pregnancy. When the active ingredient in this drug was given to pregnant animals, it increased the risk for miscarriages, poor fetal growth, and fetal malformations. If your healthcare provider recommends using Locoid, it is probably best to use the lowest effective dose for the shortest period of time possible.

Can Pregnant Women Use Locoid?

Locoid® (hydrocortisone butyrate) is a prescription steroid medication that is applied to the skin. At this time, it is unclear if the drug is safe for use during pregnancy. As with most steroids, it should be used only if necessary, at the lowest effective dose, and for the shortest possible time during pregnancy.
 

What Is Pregnancy Category C?

Locoid is classified as a pregnancy Category C drug. The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been adequately studied in pregnant humans but have caused fetal harm in animal studies.
 
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
 
Animal studies have shown that steroids, including Locoid, may increase the risk for birth defects (such as cleft palate) and may cause other problems, such as poor fetal growth or decreased survival. In animal studies, hydrocortisone butyrate (the active ingredient in Locoid) appeared to increase the risk for poor fetal growth, miscarriages, and fetal malformations. Similar problems might also occur in humans, although the risk is probably smaller for topical steroids that are applied to the skin (like Locoid).
 
While short-term use (a few days) of this drug applied to a small area of the body is probably not likely to cause problems, extended use or use over a large area of the body should probably be avoided during pregnancy if possible.
 
Pregnancy and Pain

Locoid Medication Information

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