Etanercept Dosing

Etanercept comes in injectable form and is given once or twice a week. In order for your dose of etanercept to work properly, you must take it as prescribed. You can receive the injections at your healthcare provider's office or you can give the injections to yourself at home. The dosing guidelines your healthcare provider will follow depend on factors such as your age and the medical condition you are being treated for.

An Introduction to Etanercept Dosing

The dose of etanercept (Enbrel®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your age
  • The medical condition being treated
  • Other medications you may be currently taking
  • Other medical conditions you may have.
Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis
The dosage for these conditions in adults is etanercept 50 mg per week. This can be given as a single injection or divided into two 25-mg injections given three or four days apart.
Plaque Psoriasis
The dose of etanercept for plaque psoriasis is etanercept 50 mg twice a week (three or four days apart) for the first three months, followed by etanercept 50 mg once a week. Also, lower starting dosages (25 or 50 mg per week) have also been shown to be effective.
Juvenile Rheumatoid Arthritis
For children and teens (ages 4 to 17) with juvenile rheumatoid arthritis, the etanercept dosage varies according to weight. The dose is 0.8 mg per kg per week (a little less than 0.4 mg per pound per week), up to 50 mg per week.
Children or teens who weigh 138 pounds or more can use the prefilled syringes or SureClick™ autoinjectors. However, those who weigh less must get their injections from a multiuse vial. This is because the prefilled syringes and autoinjectors contain too much etanercept, and there is no way to give a smaller dose with these devices.
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Etanercept (Enbrel)

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