Modified Cyclosporine

There are two formulations of cyclosporine (Gengraf®, Neoral®, Sandimmune®) available: an original formulation and an altered form that is more easily absorbed into the body. The original cyclosporine (Sandimmune) is approved to prevent organ rejection in people who have received a heart, kidney, or liver transplant. Modified cyclosporine (Gengraf, Neoral) is approved to treat severe psoriasis and severe, active rheumatoid arthritis in people who do not adequately respond to other treatments.
 
Cyclosporine is available in a variety of strengths and forms, including capsules, an oral liquid solution, and an intravenous (IV) injection. It is usually taken once or twice daily. Possible side effects may include kidney problems, tremors, and high blood pressure.
 
(For more detailed information on the original and modified forms, click Cyclosporine. This eMedTV Web selection offers a complete overview of this drug, including how it works, what it is approved to treat, and important safety precautions to be aware of before beginning treatment.)
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