Drug Interactions With Cyclosporine

Live Vaccinations
You should not receive live vaccinations during cyclosporine treatment. Other vaccines may be less effective during cyclosporine treatment. Therefore, talk to your healthcare provider before you receive any vaccination or immunization while taking cyclosporine.
People taking cyclosporine for psoriasis should not combine this medicine with methotrexate, due to the increased risk for skin cancer.
There have been reports of seizures in people taking cyclosporine, especially when used in combination with methylprednisolone. There have also been reports of encephalopathy, a medical term for a disease of the brain that causes altered brain function. Seek immediate medical care if you experience symptoms of encephalopathy, such as:
  • Confusion
  • Vision changes
  • Muscle weakness
  • Problems with movement
  • Seizures.
Combining cyclosporine with natalizumab may increase your risk for potentially serious infections. In general, these medications should not be taken together.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking cyclosporine with an NSAID may increase your risk for kidney problems. Your healthcare provider may need to monitor your kidneys more closely if you start taking an NSAID, or have an increase in your NSAID dose, during cyclosporine treatment.
People should not take orlistat while taking cyclosporine. Orlistat may decrease the amount of cyclosporine absorbed into your body, making the medicine less effective.
P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove cyclosporine from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
Taking cyclosporine with one of these Pgp inducers causes cyclosporine to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor your cyclosporine blood levels more closely if you take it with a Pgp inducer, and adjust your dose as needed.
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Cyclosporine Drug Information

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