Drug Interactions With Cyclosporine

CYP 3A4 Inhibitor Medications
The liver breaks down cyclosporine using enzymes known as CYP 3A4 enzymes. Some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining cyclosporine with one of these CYP 3A4 inhibitors may increase the level of cyclosporine in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take cyclosporine with a CYP 3A4 inhibitor.
Combining cyclosporine with dabigatran could increase your dabigatran blood levels, and your risk for bleeding. Talk to your healthcare provider before combining these medicines. He or she may want to monitor you more closely, or give you a lower dabigatran dose.
Cyclosporine may increase the level of digoxin in your bloodstream, which could increase your risk for serious digoxin side effects. Your healthcare provider will need to closely monitor you if you take these medicines together.
Echinacea could decrease the effectiveness of cyclosporine. Do not take echinacea while taking cyclosporine, without first talking with your healthcare provider.
Combining cyclosporine with fentanyl could increase your fentanyl blood levels to potentially unsafe levels. If your fentanyl levels become too high, you may experience serious fentanyl side effects, including dangerously slow and shallow breathing. If you take these medicines together, your healthcare provider should monitor you closely for fentanyl side effects, especially when you first start taking cyclosporine.
Grapefruit Juice
Do not consume grapefruit juice during cyclosporine treatment. Grapefruit juice may increase the amount of cyclosporine in your body, potentially increasing your risk for serious side effects.
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Cyclosporine Drug Information

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