Drug Interactions With Cyclosporine

More Detail on Drug Interactions With Cyclosporine

The following sections explain in detail the potentially negative reactions that can occur when cyclosporine is combined with any of the drugs listed above.
 
Aliskiren
Cyclosporine can increase the amount of aliskiren in your blood, possibly increasing your risk for side effects. These medicines should not be taken together.
 
Allopurinol
Allopurinol may increase the level of cyclosporine in your blood, potentially increasing your risk for cyclosporine side effects. Do not take these medicines together without first talking to your healthcare provider.
 
Certain Blood Pressure Medicines
Taking cyclosporine with an ACE inhibitor could increase your risk for kidney problems, especially if you are dehydrated. Taking cyclosporine with a calcium channel blocker may increase blood levels of both cyclosporine and the calcium channel blocker. Therefore, talk with your healthcare provider before taking cyclosporine with an ACE inhibitor or calcium channel blocker medication.
 
Colchicine
Combining cyclosporine with colchicine can increase the amount of colchicine in your body, increasing your risk for colchicine toxicity and potentially serious colchicine side effects. If you take these medicines together, your healthcare provider may need to lower your colchicine dosage.
 
CYP 3A4 Inducer Medications
The liver breaks down cyclosporine using enzymes known as CYP 3A4 enzymes. Some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining cyclosporine with one of these CYP 3A4 inducers may decrease the level of cyclosporine in your body, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take cyclosporine with a CYP 3A4 inducer.
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Cyclosporine Drug Information

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