Cyclosporine Side Effects

Headaches, nausea, and tremors are among the most commonly reported side effects with cyclosporine. However, clinical trials have shown that, in most cases, reactions such as these are typically mild and easy to treat. If you develop more serious problems, such as high fever, chest pain, or blurred vision, contact your healthcare provider right away.

An Introduction to Side Effects of Cyclosporine

Just like any medicine, cyclosporine (Gengraf®, Neoral®, Sandimmune®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with cyclosporine. Your healthcare provider can discuss a more complete list with you.)

Serious Cyclosporine Side Effects

Some cyclosporine side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of infection, such as:
    • High fever
    • Aches and pains
    • Coughing
    • Chills
  • Sores or wounds that do not heal
  • Swollen glands in the neck, armpits, or groin
  • Skin changes, such as:
    • Discoloration
    • Sores
    • Lumps
  • Breathing problems, wheezing, or shortness of breath
  • Problems with urination, such as:
    • Difficulty urinating
    • Painful urination
    • Blood in the urine
  • Signs of high blood sugar levels, such as:
    • Frequent urination
    • Increased thirst
    • Blurred vision
  • Mood or mental changes, such as:
  • Signs of anemia, such as:
    • Fatigue
    • Dizziness
    • Pale skin
  • Swelling in the arms, legs, ankles, or feet
  • Unexplained weight gain
  • Increased blood pressure (hypertension)
  • An irregular heartbeat
  • Unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Vomit that looks like coffee grounds or has bright red blood in it
  • Signs of liver problems, such as:
    • Dark urine
    • Loss of appetite
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Pain in the upper-right area of the abdomen (stomach)
  • Chest pain or discomfort
  • Seizures
  • Hearing loss
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth or throat
    • Wheezing
    • Difficulty breathing or swallowing.
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Cyclosporine Drug Information

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